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Article

The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior.

The Journal of biological chemistry - 11 May 2012

Tangredi Michelle M, Ng Fanny S, Jackson F Rob

Abstract excerpt

A detailed structure/function analysis of Drosophila p90 ribosomal S6 kinase (S6KII) or its mammalian homolog RSK has not been performed in the context of neuronal plasticity or behavior. We previously reported that S6KII is required for normal circadian periodicity. Here we report a site-directed mutagenesis of S6KII and analysis of mutants, in vivo, that identifies functional domains and phosphorylation sites...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribosomal Protein S6 Kinases, 90-kDa

Source

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Identifiers

PMID: 22447936
DOI: 10.1074/jbc.M111.315929
PMCID: PMC3351340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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