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Article

Negative feedback via RSK modulates Erk-dependent progression from naïve pluripotency.

EMBO reports - 1 Aug 2018

Nett Isabelle Re, Mulas Carla, Gatto Laurent, Lilley Kathryn S, Smith Austin

Abstract excerpt

Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signalling is implicated in initiation of embryonic stem (ES) cell differentiation. The pathway is subject to complex feedback regulation. Here, we examined the ERK-responsive phosphoproteome in ES cells and identified the negative regulator RSK1 as a prominent target. We used CRISPR/Cas9 to create combinatorial mutations in RSK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29895711
DOI: 10.15252/embr.201745642
PMCID: PMC6073214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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