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Article

Splice-site A choice targets plasma-membrane Ca2+-ATPase isoform 2 to hair bundles.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jun 2006

Hill Jennifer K, Williams Diane E, LeMasurier Meredith, Dumont Rachel A, Strehler Emanuel E, Gillespie Peter G

Abstract excerpt

Localization of mechanotransduction in sensory hair cells to hair bundles requires selective targeting of essential proteins to specific locations. Isoform 2 of the plasma-membrane Ca2+-ATPase (PMCA2), required for hearing and balance, is found exclusively in hair bundles. We determined the contribution of splicing at the two major splicing sites (A and C) to hair-cell targeting of PMCA2. When PMCA2 isoforms were...

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Identifiers

PMID: 16763025
DOI: 10.1523/JNEUROSCI.0447-06.2006
PMCID: PMC2204085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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