Article
PMCA2 pump mutations and hereditary deafness.
Neuroscience letters - 10 Jan 2018
Bortolozzi Mario, Mammano Fabio
Abstract excerpt
Hair cells of the inner ear detect sound stimuli, inertial or gravitational forces by deflection of their apical stereocilia. A small number of stereociliary cation-selective mechanotransduction (MET) channels admit K+ and Ca2+ ions into the cytoplasm promoting hair cell membrane depolarization and, consequently, neurotransmitter release at the cell basolateral pole. Ca2+ influx into the stereocilia compartment...
Topics
- Animals
- Genetic Diseases, Inborn
- Hair Cells, Auditory, Inner
- Hearing Loss, Sensorineural
- Humans
- Mutation
- Plasma Membrane Calcium-Transporting ATPases
- Protein Isoforms