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Article

PMCA2 pump mutations and hereditary deafness.

Neuroscience letters - 10 Jan 2018

Bortolozzi Mario, Mammano Fabio

Abstract excerpt

Hair cells of the inner ear detect sound stimuli, inertial or gravitational forces by deflection of their apical stereocilia. A small number of stereociliary cation-selective mechanotransduction (MET) channels admit K+ and Ca2+ ions into the cytoplasm promoting hair cell membrane depolarization and, consequently, neurotransmitter release at the cell basolateral pole. Ca2+ influx into the stereocilia compartment...

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Share to MET gene
Share to Genetic Diseases, Inborn
Share to Hair Cells, Auditory, Inner

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hearing Loss, Sensorineural

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Share to Plasma Membrane Calcium-Transporting ATPases

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Source

Identifiers

PMID: 29452611
DOI: 10.1016/j.neulet.2017.09.059

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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