Article
Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit.
The Journal of biological chemistry - 4 Sept 1998
Chien A J, Gao T, Perez-Reyes E, Hosey M M
Abstract excerpt
In this study, we report that palmitoylation was a critical determinant of the subcellular localization of the rat beta2a subunit of voltage-dependent calcium channels. Immunohistochemical staining of transfected cells revealed that a palmitoylation-deficient beta2a subunit exhibited a diffuse in...
Topics
- Amino Acid Sequence
- Animals
- Anti-Bacterial Agents
- Biological Transport
- Brefeldin A
- Calcium Channels
- Calcium Channels, L-Type
- Cell Compartmentation
- Cyclopentanes
- Cysteine
- Macrolides
- Molecular Sequence Data
- Mutation
- Palmitic Acid
- Protein Processing, Post-Translational
- Protein Synthesis Inhibitors
- Rabbits
- Rats