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Article

Tonotopic Specialization of MYO7A Isoforms in Auditory Hair Cells

2025-04-03

Abstract excerpt

1. Mutations in Myo7a cause Usher syndrome type 1B and non-syndromic deafness, but the precise function of MYO7A in sensory hair cells remains unclear. We identify and characterize a novel isoform, MYO7A-N, expressed in auditory hair cells alongside the canonical MYO7A-C. Isoform-specific knock-in mice reveal that inner hair cells primarily express MYO7A-C, while outer hair cells express both isoforms in opposing...

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Literature Corpus work
d07fa6e5-f73a-554e-84c7-7f66268c8677
DOI
10.1101/2025.04.01.646665
Open publication

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Tonotopic Specialization of MYO7A Isoforms in Auditory Hair CellsDOI 10.1101/2025.04.01.646665
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