Article
Mutations in ap1b1 cause mistargeting of the Na(+)/K(+)-ATPase pump in sensory hair cells.
PloS one - 1 Jan 2013
Clemens Grisham Rachel, Kindt Katie, Finger-Baier Karin, Schmid Bettina, Nicolson Teresa
Abstract excerpt
The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle. Mechanotransduction occurs within the hair bundle, whereas synaptic transmission takes place at the basolateral membrane. The molecular basis of the development and maintenance of the apical and basal compartments in sensory hair cells is poorly understood. Here we...
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