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Article

Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations.

European journal of clinical pharmacology - 1 Jun 2007

Jada Srinivasa Rao, Xiaochen Shu, Yan Liu Yan, Xiaoqiang Xiang, Lal Suman, Zhou Shu Feng, Ooi London Lucien, Chowbay Balram

Abstract excerpt

OBJECTIVE: The aim of this study was to characterize the population frequency of SLCO1B1 polymorphic variants in three distinct healthy Asian populations, namely Chinese (n = 100), Malay (n = 100) and Indian (n = 100), and to explore the association between haplotype-tagged single nucleotide polymorphisms (htSNPs) on hepatic SLCO1B1 mRNA expression. METHODS: The distribution of polymorphic variants in the SLCO1B1...

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Asian People
China
India
Liver
Liver-Specific Organic Anion Transporter 1

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Organic Anion Transporters

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PMID: 17415554
DOI: 10.1007/s00228-007-0285-5

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