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Article

Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability.

Pharmacogenetics and genomics - 1 Jan 2010

Ho Richard H, Leake Brenda F, Kilkenny Dawn M, Meyer Zu Schwabedissen Henriette E, Glaeser Hartmut, Kroetz Deanna L, Kim Richard B

Abstract excerpt

OBJECTIVES: Our aims were to identify and functionally characterize coding region nonsynonymous single nucleotide polymorphisms in the hepatic efflux transporter, bile salt export pump (BSEP; ABCB11), and to assess interindividual variability in BSEP expression. METHODS: We identified 24 single nucleotide polymorphisms, including nine nonsynonymous variants, in ABCB11 from genomic DNA of approximately 250...

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Source

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Identifiers

PMID: 20010382
DOI: 10.1097/FPC.0b013e3283349eb0
PMCID: PMC2883163

Genes

ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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