Article
Localization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell.
Molecular biology of the cell - 1 Jan 2003
Temme Achim, Rieger Michael, Reber Friedemann, Lindemann Dirk, Weigle Bernd, Diestelkoetter-Bachert Petra, Ehninger Gerhard, Tatsuka Masaaki, Terada Yasuhiko, Rieber Ernst Peter
Abstract excerpt
Survivin, a member of the inhibitor of apoptosis protein family, has attracted growing attention due to its expression in various tumors and its potential application in tumor therapy. However, its subcellular localization and function have remained controversial: Recent studies revealed that survivin is localized at the mitotic spindle, binds caspases, and could thus protect cells from apoptosis. The cell...
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