Article
Functional characterization of a mutated chicken alpha7 nicotinic acetylcholine receptor subunit with a leucine residue inserted in transmembrane domain 2.
British journal of pharmacology - 1 Jun 1998
Buckingham S D, Adcock C, Sansom M S, Sattelle D B, Baylis H A
Abstract excerpt
1. Site-directed mutagenesis was used to create an altered form of the chicken alpha7 nicotinic acetylcholine (ACh) receptor subunit (alpha7x61) in which a leucine residue was inserted between residues Leu9' and Ser10' in transmembrane domain 2. The properties of alpha7x61 receptors are distinct...
Topics
- Acetylcholine
- Amino Acid Sequence
- Animals
- Anthelmintics
- Base Sequence
- Chickens
- Dihydro-beta-Erythroidine
- Female
- In Vitro Techniques
- Leucine
- Levamisole
- Membrane Potentials
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nicotine
- Nicotinic Agonists
- Oocytes