Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of Mouse p53 Ser23 and the Response to DNA Damage

1 Apr 2002

Abstract excerpt

Recent studies have suggested that phosphorylation of human p53 at Ser20 is important for stabilizing p53 in response to DNA damage through disruption of the interaction between MDM2 and p53. To examine the requirement for this DNA damage-induced phosphorylation event in a more physiological setting, we introduced a missense mutation into the endogenous p53 gene of mouse embryonic stem (ES) cells that changes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11909939
DOI: 10.1128/mcb.22.8.2441-2449.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of Mouse p53 Ser23 and the Response to DNA DamagePMID 11909939Read ↗

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.Semantic proximity Read ↗

Puma is required for p53-induced depletion of adult stem cells.Semantic proximity Read ↗

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.Semantic proximity Read ↗

Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.Semantic proximity Read ↗

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.Semantic proximity Read ↗

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.Semantic proximity Read ↗

Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.Semantic proximity Read ↗

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.Semantic proximity Read ↗

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 ResponsesSemantic proximity Read ↗

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.Semantic proximity Read ↗

Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation.Semantic proximity Read ↗

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.