Article
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
Communications biology - 3 Jan 2026
Wang Erli, Cao Liangzi, Guo Wendong, Dong Xiang, Zhang Wanying, Zhang Xiaowen, Wang Zhuo, Chen Xia, Li Aicun, Zou Yu, Li Shikun, Chen Kedian, Su Han, Cao Sunrun, Du Ning, Wang Pingyuan, Hwang Paul M, Liu Xiangsheng, Song Xiaoyu, Xu Hongde, Liu Jingwei, Cao Liu
Abstract excerpt
Li-Fraumeni Syndrome (LFS) is linked to mutations in the p53 gene and is characterized by autosomal dominant early-onset familial cancer susceptibility. The p53R181C mutation is one of the earliest described mutations associated with early-onset familial hereditary breast cancer. Highly stable mutant p53 protein is often a prerequisite for tumor initiation and progression, but the pathways leading to p53R181C...
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