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Article

Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Kedzierska Katherine, Venturi Vanessa, Field Kenneth, Davenport Miles P, Turner Stephen J, Doherty Peter C

Abstract excerpt

Single-cell analysis of endogenous, primary CD8(+) T cell responses to the influenza D(b)NP(366) and D(b)PA(224) epitopes indicates that prominent clonotypes bearing "public" or "shared" T cell receptors (TCRs) subset early into CD62L(hi) and CD62L(lo) populations. The CD62L(lo) effectors divide more and are rapidly eliminated during the contraction phase, whereas stable CD62L(hi) memory populations persist in...

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Identifiers

PMID: 16754852
DOI: 10.1073/pnas.0603289103
PMCID: PMC1482587

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Source receipt: pubmed, retrieved 7 Sept 2026.

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