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Article

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.

The Journal of clinical investigation - 1 Feb 2018

Pizzolla Angela, Nguyen Thi Ho, Sant Sneha, Jaffar Jade, Loudovaris Tom, Mannering Stuart I, Thomas Paul G, Westall Glen P, Kedzierska Katherine, Wakim Linda M

Abstract excerpt

The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate rapid protection against respiratory pathogens such as influenza virus, a highly contagious respiratory pathogen that continues to be a major public health burden. Animal models show that influenza-specific lung CD8+ Trm cells are indispensable for crossprotection against pulmonary...

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Source

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Identifiers

PMID: 29309047
DOI: 10.1172/JCI96957
PMCID: PMC5785253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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