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Article

CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence.

Cell reports - 4 Feb 2020

Krummey Scott M, Morris Anna B, Jacobs Jesica R, McGuire Donald J, Ando Satomi, Tong Katherine P, Zhang Weiwen, Robertson Jennifer, Guasch Sara A, Araki Koichi, Larsen Christian P, Evavold Brian D, Kissick Haydn T, Ford Mandy L

Abstract excerpt

The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RBhi and CD45RBlo populations. Relative to CD45RBlo memory T cells, CD45RBhi memory T cells have lower affinity and display greater clonal diversity, as well as a persistent...

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Share to Antibody Affinity
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 32023448
DOI: 10.1016/j.celrep.2020.01.016
PMCID: PMC7155808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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