Article
Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.
PLoS pathogens - 1 Oct 2015
Martin Matthew D, Kim Marie T, Shan Qiang, Sompallae Ramakrishna, Xue Hai-Hui, Harty John T, Badovinac Vladimir P
Abstract excerpt
Memory CD8 T cells confer increased protection to immune hosts upon secondary viral, bacterial, and parasitic infections. The level of protection provided depends on the numbers, quality (functional ability), and location of memory CD8 T cells present at the time of infection. While primary memory CD8 T cells can be maintained for the life of the host, the full extent of phenotypic and functional changes that...
Topics
- Adoptive Transfer
- Animals
- Arenaviridae Infections
- CD8-Positive T-Lymphocytes
- Disease Models, Animal
- Immunologic Memory
- Immunophenotyping
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Oligonucleotide Array Sequence Analysis