Article
Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection.
European journal of immunology - 1 Mar 2011
Croom Hayley A, Denton Alice E, Valkenburg Sophie A, Swan Natasha G, Olson Matthew R, Turner Stephen J, Doherty Peter C, Kedzierska Katherine
Abstract excerpt
The mechanistic basis of memory T-cell development is poorly defined. Phenotypic markers that define precursors at effector stages have been characterized for acute systemic infections with high antigen load. We asked whether such markers can identify memory precursors from early effectors (d6) to late memory (>d500) for two immunodominant CD8(+) responses during the course of a localized low-load influenza...
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