Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells.

doi:10.1016/j.celrep.2021.109286

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells.

Cell reports - 22 Jun 2021

Mathew Nimitha R, Jayanthan Jayalal K, Smirnov Ilya V, Robinson Jonathan L, Axelsson Hannes, Nakka Sravya S, Emmanouilidi Aikaterini, Czarnewski Paulo, Yewdell William T, Schön Karin, Lebrero-Fernández Cristina, Bernasconi Valentina, Rodin William, Harandi Ali M, Lycke Nils, Borcherding Nicholas, Yewdell Jonathan W, Greiff Victor, Bemark Mats, Angeletti Davide

Abstract excerpt

B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B cell receptor (BCR) sequencing of antigen-specific cells in lymph nodes, spleen, and lungs after influenza infection in mice, we identify several germinal center...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germinal Center

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza, Human

Share to Mutation Rate

Share to Plasma Cells

Share to Receptors, Antigen, B-Cell

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 34161770
DOI: 10.1016/j.celrep.2021.109286
PMCID: PMC7612943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells.PMID 34161770Read ↗

Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics.Semantic proximity Read ↗

Transcriptional program of memory B cell activation, broadly binding anti-influenza antibodies, and bystander activation after vaccination revealed by single-cell transcriptomicsSemantic proximity Read ↗

High-resolution single-cell atlas of the human B cell compartment and immune microenvironment across tissuesSemantic proximity Read ↗

A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity Read ↗

Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccinationSemantic proximity Read ↗

Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infectionSemantic proximity Read ↗

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturationSemantic proximity Read ↗

A dynamic activation–memory cycle organizes the human IgG⁺ memory B cell compartmentSemantic proximity Read ↗

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunitySemantic proximity Read ↗

Memory B cells dominate the early antibody-secreting cell response to SARS-CoV-2 mRNA vaccination in naïve individuals independently of their antibody affinitySemantic proximity Read ↗

Deep profiling of antigen-specific B cells from different pathogens identifies novel compartments in the IgG memory B cell and antibody-secreting cell lineagesSemantic proximity Read ↗

Lineage structure of the human antibody repertoire in response to influenza vaccination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.