Article
Impact of CD8-MHC class I interaction in detection and sorting efficiencies of antigen-specific T cells using MHC class I/peptide multimers: contribution of pMHC valency.
International immunology - 1 Jul 2006
Neveu Berangere, Echasserieau Klara, Hill Timothy, Kuus-Reichel Kristine, Houssaint Elisabeth, Bonneville Marc, Saulquin Xavier
Abstract excerpt
Recombinant soluble multimeric forms of MHC class I molecules loaded with antigenic peptides (pMHC) have turned out to be particularly useful to detect and isolate specific T cells. These applications both rely on the oligomerization of pMHC monomers in order to compensate for their inherent low affinity for the TCR. In this study, we have evaluated the precise contribution of CD8-pMHC interaction on the...
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