Article
Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis.
Journal of hepatology - 1 Nov 2006
Bowlus Christopher L, Karlsen Tom H, Broomé Ulrika, Thorsby Erik, Vatn Morten, Schrumpf Erik, Lie Benedicte A, Boberg Kirsten Muri
Abstract excerpt
BACKGROUND/AIMS: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this...
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