Article
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry.
HLA - 1 Oct 2017
Henriksen E K K, Viken M K, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov J R, Lazaridis K N, Juran B D, Chazouillères O, Färkkilä M, Gotthardt D N, Invernizzi P, Carbone M, Hirschfield G M, Rushbrook S M, Goode E, Ponsioen C Y, Weersma R K, Eksteen B, Yimam K K, Gordon S C, Goldberg D, Yu L, Bowlus C L, Franke A, Lie B A, Karlsen T H
Abstract excerpt
Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the...
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