Article
Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis.
The American journal of gastroenterology - 1 Jan 2007
Karlsen Tom H, Hampe Jochen, Wiencke Kristine, Schrumpf Erik, Thorsby Erik, Lie Benedicte A, Broomé Ulrika, Schreiber Stefan, Boberg Kirsten Muri
Abstract excerpt
OBJECTIVES: Approximately 80% of patients with primary sclerosing cholangitis (PSC) of Northern European origin have concurrent inflammatory bowel disease (IBD). The majority have ulcerative colitis, but there is also an association with Crohn's colitis. The pathogenetic link between PSC and IBD is unknown. We aimed to assess whether genetic risk factors in PSC can be identified on the basis of known IBD...
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