Article
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Neurobiology of disease - 1 Aug 2006
Greggio Elisa, Jain Shushant, Kingsbury Ann, Bandopadhyay Rina, Lewis Patrick, Kaganovich Alice, van der Brug Marcel P, Beilina Alexandra, Blackinton Jeff, Thomas Kelly Jean, Ahmad Rili, Miller David W, Kesavapany Sashi, Singleton Andrew, Lees Andrew, Harvey Robert J, Harvey Kirsten, Cookson Mark R
Abstract excerpt
Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found throughout the gene including the kinase domain. However, it is not clear if kinase activity is important for the damaging effects of pathogenic mutations. In this study, we noted two cellular phenotypes associated with mutant dardarin. First, pathogenic...
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