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Article

Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.

PloS one - 1 Jan 2016

Melachroinou Katerina, Leandrou Emmanouela, Valkimadi Polytimi-Eleni, Memou Anna, Hadjigeorgiou Georgios, Stefanis Leonidas, Rideout Hardy J

Abstract excerpt

BACKGROUND: Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. OBJECTIVE: We examined multiple properties of LRRK2 behavior in cellular models over-expressing three sequence variants described in Greek PD patients in comparison to several known pathogenic and non-pathogenic LRRK2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27832104
DOI: 10.1371/journal.pone.0166053
PMCID: PMC5104429

Genes

FADD

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