Article
Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells.
Cancer research - 1 Jun 2003
Gurova Katerina V, Rokhlin Oskar W, Budanov Andrei V, Burdelya Ludmila G, Chumakov Peter M, Cohen Michael B, Gudkov Andrei V
Abstract excerpt
Both inactivation of p53 function and loss of sensitivity to Fas contribute to a malignant phenotype and frequently occur during tumor progression. Although in the majority of cases only one of the p53 alleles is mutated, some tumors acquire mutations in both alleles of the p53 gene. To determine the biological significance of this phenomenon, we analyzed p53 mutants, p53(223Leu) and p53(274Phe), from...
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