The coincidence of chromosome 15 aberrations and beta2-microglobulin gene mutations is causative for the total loss of human leukocyte antigen class I expression in melanoma.

doi:10.1158/1078-0432.CCR-05-2174

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Article

The coincidence of chromosome 15 aberrations and beta2-microglobulin gene mutations is causative for the total loss of human leukocyte antigen class I expression in melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2006

Paschen Annette, Arens Norbert, Sucker Antje, Greulich-Bode Karin M, Fonsatti Ester, Gloghini Annunziata, Striegel Sandra, Schwinn Nicole, Carbone Antonino, Hildenbrand Ralf, Cerwenka Adelheid, Maio Michele, Schadendorf Dirk

Abstract excerpt

PURPOSE: Total loss of surface presentation of human leukocyte antigen (HLA) class I molecules, protecting tumor cells from the recognition by cytotoxic host CD8+ T cells, is known to be caused by mutations in the beta2-microglobulin (beta2m) gene. We asked whether abnormalities of chromosome 15, harboring the beta2m gene on 15q21, in addition to beta2m gene mutations, are causative for the HLA class I-negative...

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PMID: 16740750
DOI: 10.1158/1078-0432.CCR-05-2174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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