Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human leukocyte antigen class I gene mutations in cervical cancer.

Journal of the National Cancer Institute - 6 Oct 1999

Koopman L A, van Der Slik A R, Giphart M J, Fleuren G J

Abstract excerpt

BACKGROUND: Various mechanisms contribute to the loss of human leukocyte antigen (HLA) class I expression that is frequently observed in cancers. Although some single allele losses have been ascribed to mutations in HLA class I genes, direct evidence for this phenomenon in vivo is still lacking. Thus, we investigated whether HLA class I gene mutations could account for the loss of allele-specific expression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 6
Share to DNA Primers
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Phenotype

Share to Polymerase Chain Reaction

Share to Tumor Cells, Cultured

Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 10511595
DOI: 10.1093/jnci/91.19.1669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human leukocyte antigen class I gene mutations in cervical cancer.PMID 10511595Read ↗

HLA class I phenotype and genotype alterations in cervical carcinomas and derivative cell lines.Semantic proximity Read ↗

Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer.Semantic proximity Read ↗

Multiple mechanisms underlie HLA dysregulation in cervical cancer.Semantic proximity Read ↗

The expression of histocompatibility-related leukocyte antigens in the pathway to cervical carcinoma.Semantic proximity Read ↗

High frequency of altered HLA class I phenotypes in laryngeal carcinomas.Semantic proximity Read ↗

A mutation determining the loss of HLA-A2 antigen expression in a cervical carcinoma reveals novel splicing of human MHC class I classical transcripts in both tumoral and normal cells.Semantic proximity Read ↗

Human leukocyte antigen class I allelic and haplotype loss in squamous cell carcinoma of the head and neck: clinical and immunogenetic consequences.Semantic proximity Read ↗

HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis.Semantic proximity Read ↗

Cervical carcinoma: low frequency of allele loss at loci implicated in other common malignancies.Semantic proximity Read ↗

Altered HLA expression by metastatic cervical carcinoma cells as a factor in impaired immune surveillance.Semantic proximity Read ↗

Analysis of HLA-E expression in human tumors.Semantic proximity Read ↗

The coincidence of chromosome 15 aberrations and beta2-microglobulin gene mutations is causative for the total loss of human leukocyte antigen class I expression in melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.