Genomic structure, expression and mutational analysis of the P15 (MTS2) gene.

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Article

Genomic structure, expression and mutational analysis of the P15 (MTS2) gene.

Oncogene - 7 Sept 1995

Stone S, Dayananth P, Jiang P, Weaver-Feldhaus J M, Tavtigian S V, Cannon-Albright L, Kamb A

Abstract excerpt

The P15 gene (MTS2) encodes a cyclin-dependent kinase (CDK) inhibitor with considerable sequence identity and biochemical similarity to the CDK inhibitor p16. It is closely linked to the P16 gene (MTS1) and is homozygously deleted in many tumor cell lines. These features suggest that p15 may be a...

Topics

Base Sequence
Carrier Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Humans
Melanoma
Molecular Sequence Data
Mutation
Protein Kinase Inhibitors
RNA, Messenger
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 7675459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7675459-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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