Article
Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.
Cancer research - 15 Apr 2007
Rosenberg Daniel W, Yang Shi, Pleau Devon C, Greenspan Emily J, Stevens Richard G, Rajan Thiruchandurai V, Heinen Christopher D, Levine Joel, Zhou Yijian, O'Brien Michael J
Abstract excerpt
We previously reported that colon carcinomas, adenomas, and hyperplastic polyps exhibiting a serrated histology were very likely to possess BRAF mutations, whereas when these same advanced colonic lesions exhibited non-serrated histology, they were wild type for BRAF; among hyperplastic polyps, KRAS mutations were found mainly in a non-serrated variant. On this basis, we predicted that hyperplastic aberrant crypt...
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