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Article

Distinct Transcriptional Changes and Epithelial–Stromal Interactions Are Altered in Early-Stage Colon Cancer Development

29 Jun 2016

Abstract excerpt

UNLABELLED: Although the progression of mutated colonic cells is dependent upon interactions between the initiated epithelium and surrounding stroma, the nature of these interactions is poorly understood. Here, the development of an ultrasensitive laser capture microdissection (LCM)/RNA-seq approach for studying the epithelial and stromal compartments of aberrant crypt foci (ACF) is described. ACF are the...

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Share to Colorectal Cancer Screening and Detection
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PMID: 27353028
DOI: 10.1158/1541-7786.mcr-16-0156

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