Article
Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.
Human molecular genetics - 15 Jul 2006
Yu Yi, Panhuysen Carolien, Kranzler Henry R, Hesselbrock Victor, Rounsaville Bruce, Weiss Roger, Brady Kathleen, Farrer Lindsay A, Gelernter Joel
Abstract excerpt
We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND using the Fagerstrom Test for Nicotine Dependence (FTND). We genotyped 18 single nucleotide polymorphisms (SNPs) spanning a region of approximately 210 kb that includes DDC and the genes immediately flanking DDC in...
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