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Article

Exploring allele specific methylation in drug dependence susceptibility.

Journal of psychiatric research - 1 Apr 2021

Pineda-Cirera Laura, Cabana-Domínguez Judit, Grau-López Lara, Daigre Constanza, Sánchez-Mora Cristina, Palma-Álvarez Raul Felipe, Ramos-Quiroga Josep Antoni, Ribasés Marta, Cormand Bru, Fernàndez-Castillo Noèlia

Abstract excerpt

Drug dependence is a neuropsychiatric condition that involves genetic, epigenetic and environmental factors. Allele-specific methylation (ASM) is a common and stable epigenetic mechanism that involves genetic variants correlating with differential levels of methylation at CpG sites. We selected 182 single-nucleotide polymorphisms (SNPs) described to influence cis ASM in human brain regions to evaluate their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32917399
DOI: 10.1016/j.jpsychires.2020.07.044

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