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Article

Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.

Human molecular genetics - 15 Jun 2005

Ma Jennie Z, Beuten Joke, Payne Thomas J, Dupont Randolph T, Elston Robert C, Li Ming D

Abstract excerpt

DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Because the mesolimbic dopaminergic system is implicated in the reinforcing effects of many drugs, including nicotine, the DDC gene is considered a plausible candidate for involvement in the development of vulnerability to nicotine dependence (ND). Further, this gene is...

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Identifiers

PMID: 15879433
DOI: 10.1093/hmg/ddi177

Genes

DDC

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Related research

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Research trail→

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Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.PMID 15879433Read ↗

DOPA decarboxylase gene is associated with nicotine dependence.Semantic proximity Read ↗

Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.Semantic proximity Read ↗

Significant association of DRD1 with nicotine dependence.Semantic proximity Read ↗

Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans.Semantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.Semantic proximity Read ↗

Polymorphisms in HTR2A and DRD4 Predispose to Smoking and Smoking Quantity.Semantic proximity Read ↗

Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: results from a large multicenter association study.Semantic proximity Read ↗

Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers.Semantic proximity Read ↗

Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence.Semantic proximity Read ↗

Dissection of the phenotypic and genotypic associations with nicotinic dependence.Semantic proximity Read ↗

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence.Semantic proximity Read ↗

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