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Article

Consequence of Gastrin-Releasing Peptide Receptor Activation in a Human Colon Cancer Cell Line: A Proteomic Approach

4 May 2006

Abstract excerpt

Gastrin-releasing peptide (GRP) and its receptor (GRPR) are aberrantly up-regulated in colon cancer. When expressed, they act as morphogens, retaining tumor cells in a better differentiated state and retarding metastasis. To identify targets activated in response to GRPR signaling we studied Caco-2 and HT-29 cells, colon cancer cell lines that expresses GRPR as a function of confluence. Total cell protein was...

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PMID: 16739997
DOI: 10.1021/pr060005g

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