Article
The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon.
Molecular cancer - 18 Mar 2015
Aggarwal Abhishek, Prinz-Wohlgenannt Maximilian, Gröschel Charlotte, Tennakoon Samawansha, Meshcheryakova Anastasia, Chang Wenhan, Brown Edward M, Mechtcheriakova Diana, Kállay Enikö
Abstract excerpt
BACKGROUND: The calcium sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is expressed also in tissues not directly involved in calcium homeostasis like the colon. We have previously reported that CaSR expression is down-regulated in colorectal cancer (CRC) and that loss of CaSR provides growth advantage to transformed cells. However, detailed mechanisms underlying these processes are largely...
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