Article
Increased frequency of gastrin-releasing peptide receptor gene mutations during colon-adenocarcinoma progression.
Molecular carcinogenesis - 1 May 2003
Glover Sarah C, Tretiakova Maria S, Carroll Robert E, Benya Richard V
Abstract excerpt
Epithelial cells lining the mature human colon do not normally express receptors for gastrin-releasing peptide (GRPR). In contrast, we have shown that when aberrantly expressed in functional form in colon cancer, this protein acted as a morphogen where it caused tumor cells to adopt a better-differentiated phenotype. Importantly, GRPR mRNA is ubiquitously mutated in human colon cancer cell lines, with...
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