Article

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

2020-07-10

Abstract excerpt

The calcium-sensing receptor (CaSR) is a ubiquitously expressed multifunctional G protein-coupled receptor. Several studies reported that the CaSR plays an anti-inflammatory and anti-tumorigenic role in the intestine, and that it is down-regulated during colorectal carcinogenesis. We hypothesized that intestine-specific positive allosteric CaSR modulators (type II calcimimetics) could be used for the treatment of...

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Literature Corpus work: c8c605e1-719e-52dd-9eb5-8d17c2999078
DOI: 10.1101/2020.07.09.195255

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