Article
Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract.
Mechanisms of development - 1 May 2002
Carroll Robert E, Matkowskyj Kristina, Saunthararajah Yogen, Sekosan Marin, Battey James F, Benya Richard V
Abstract excerpt
Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer might reflect a re-capitulation of a normal role in regulating intestinal organogenesis. To...
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