Article
The polymorphisms of the CYP17 and CYP19 genes in endometrial cancer patients.
Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2006
Szyłło Krzysztof, Smolarz Beata, Romanowicz-Makowska Hanna, Kulig Andrzej
Abstract excerpt
Endogenous estrogen exposure is an important determinant of endometrial cancer risk. The CYP 17 and CYP 19 genes encode 17alphahydroxylase/17,20-lyase and aromatase, respectively, both involved in sex hormone synthesis. The genes CYP17 and CYP19 are polymorphic and gene variability could contribute to the level of protein biosynthesis. In the present work the distribution of genotypes and frequency of alleles of...
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