Article
[A polymorphism study of the CYP19 gene in endometrial cancer patients].
Voprosy onkologii - 1 Jan 2000
Bershteĭn L M, Imianitov E N, Suspitsyn E N, Grigor'ev M Iu, Sokolov E P, Togo A V, Khanson K P, Poroshina T E, Gamaiunova V B, Vasil'ev D A, Kovalevskiĭ A Iu, Volkov O N
Abstract excerpt
A strong connection is known to exist between initiation/promotion of endometrial cancer and excess of estrogens. Therefore, participation of certain alleles of genetic polymorphisms in steroid biosynthesis or metabolism may be responsible for predisposition to the disease. The present study, comparing CYP19 (aromatase) gene polymorphism in 85 patients and 110 healthy females, pointed to a more frequent...
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