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Article

The CYP17 and CYP19 gene single nucleotide polymorphism in women with sporadic breast cancer.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2009

Sobczuk Anna, Romanowicz Hanna, Fiks Tomasz, Połać Ireneusz, Smolarz Beata

Abstract excerpt

The cytochrome P450 family (CYPs) enzymes play an important role in the metabolism of environmental carcinogens and of oestrogen and can affect breast cancer risk. We hypothesise that polymorphisms of CYP17 and CYP19 gene can predict higher incidence of breast cancer. In the present work the distribution of genotypes and frequency of alleles of the T/C polymorphism in promoter region of CYP17 and Trp/Arg...

Topics

Aged
Aged, 80 and over
Aromatase
Breast Neoplasms
Carcinoma, Ductal, Breast
Case-Control Studies
Female
Gene Frequency
Genotype
Humans
Incidence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Poland

Polymorphism, Single Nucleotide

Risk Factors

Steroid 17-alpha-Hydroxylase

Source

Identifiers

PMID: 20072949

Provenance

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