Article
Genetic variation of the CYP17 and susceptibility to endometrial cancer: a meta-analysis.
Molecular biology reports - 1 Aug 2013
Xu Jun, Lin Xiao, Zhu Haoping, Zhang Zhiling, Yang Baohua
Abstract excerpt
Excessive estrogenic influence is known to be associated with initiation/promotion of endometrial cancer (EC). Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of EC. Cytochrome P450c17α (CYP17), a gene that codes for a key enzyme (cytochrome P450c17α) in a rate-limiting step of estrogen biosynthesis has attracted considerable attention as a candidate gene...
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