Article
Verapamil reverses the ultrastructural alterations in the plasma membrane induced by drug resistance.
FEBS letters - 21 Dec 1992
García-Segura L M, Soto F, Planells-Cases R, Gonzalez-Ros J M, Ferragut J A
Abstract excerpt
Two P388 cell sublines with different levels of resistance to daunomycin (DNM), P388/20 and P388/100 cells (approximately 20- and 100-fold resistance, respectively), undergo a significant (approximately 2-fold) increase in the number of intramembrane particles (IMPs) present at their plasma membrane, as compared to that exhibited by the parental, drug-sensitive P388 (P388/S) cell line. Regardless of the level of...
Topics
- Animals
- Cell Membrane
- Daunorubicin
- Drug Resistance
- Freeze Fracturing
- Leukemia P388
- Membrane Glycoproteins
- Mice
- Phenotype
- Tumor Cells, Cultured
- Verapamil