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Article

Biphasic Ca2+-dependent switching in a calmodulin-IQ domain complex.

Biochemistry - 6 Jun 2006

Black D J, Leonard Jared, Persechini Anthony

Abstract excerpt

The relationship between the free Ca2+ concentration and the apparent dissociation constant for the complex between calmodulin (CaM) and the neuromodulin IQ domain consists of two phases. In the first phase, Ca2+ bound to the C-ter EF hand pair in CaM increases the Kd for the complex from the Ca2+-free value of 2.3 +/- 0.1 microM to a value of 14.4 +/- 1.3 microM. In the second phase, Ca2+ bound to the N-ter EF...

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Identifiers

PMID: 16734434
DOI: 10.1021/bi052533w
PMCID: PMC2532102

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