Article
Genotypic differences between C57BL/6 and A inbred mice in anxiolytic and sedative actions of diazepam.
Behavior genetics - 1 Mar 1998
Garrett K M, Niekrasz I, Haque D, Parker K M, Seale T W
Abstract excerpt
The role of genotype in susceptibility to the behavioral actions of benzodiazepines is not well characterized. To develop a model for such studies, we have characterized the anxiolytic and sedative activities of diazepam in C57BL/6J and A/J inbred mice. C57BL/6J mice were more responsive than A/J mice to diazepam-induced anxiolytic-like activity in the mirrored chamber aversion assay and the elevated plus-maze...
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