Genotypic differences between C57BL/6 and A inbred mice in anxiolytic and sedative actions of diazepam.

doi:10.1023/a:1021424108213

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Article

Genotypic differences between C57BL/6 and A inbred mice in anxiolytic and sedative actions of diazepam.

Behavior genetics - 1 Mar 1998

Garrett K M, Niekrasz I, Haque D, Parker K M, Seale T W

Abstract excerpt

The role of genotype in susceptibility to the behavioral actions of benzodiazepines is not well characterized. To develop a model for such studies, we have characterized the anxiolytic and sedative activities of diazepam in C57BL/6J and A/J inbred mice. C57BL/6J mice were more responsive than A/J...

Topics

Animals
Anti-Anxiety Agents
Arousal
Diazepam
Dose-Response Relationship, Drug
Genotype
Male
Maze Learning
Mice
Mice, Inbred A
Mice, Inbred C57BL
Receptors, Serotonin
Receptors, Serotonin, 5-HT1
Species Specificity

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