Article
Genetic variation in low-dose effects of neonatal DES exposure in female rats.
Reproductive toxicology (Elmsford, N.Y.) - 1 Oct 2017
Ohmukai Hideo, Negura Tsukasa, Tachibana Shigehiro, Ohta Ryo
Abstract excerpt
To confirm genetic variation in low-dose effects of diethylstilbestrol (DES), two inbred strains of rats, which have been selectively bred for high- and low-avoidance learning (HAA and LAA, respectively), were used in this study. LAA rats characteristically show later sexual maturation, earlier reproductive senescence, and lower body weight as compared to HAA rats. Female neonates of each strain were daily...
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