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Article

Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances.

Journal of toxicology and environmental health - 1 Jan 1996

Kacew S, Festing M F

Abstract excerpt

The development of drugs to combat diseases, chemicals to improve food production, or compounds to enhance the quality of life necessitates, by law, the use of laboratory animals to test their safety. In order to simulate the human condition it is necessary to choose a species in which pharmacokinetic and toxicokinetic mechanisms are established and resemble those of humans. The advantages of the use of the rat...

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PMID: 8568909
DOI: 10.1080/009841096161960-2840

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