Article
Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances.
Journal of toxicology and environmental health - 1 Jan 1996
Kacew S, Festing M F
Abstract excerpt
The development of drugs to combat diseases, chemicals to improve food production, or compounds to enhance the quality of life necessitates, by law, the use of laboratory animals to test their safety. In order to simulate the human condition it is necessary to choose a species in which pharmacoki...
Topics
- Animals
- Animals, Genetically Modified
- Disease Susceptibility
- Drug Resistance
- Drug-Related Side Effects and Adverse Reactions
- Genotype
- Humans
- Kidney
- Liver
- Lung
- Nervous System
- Rats
- Rats, Inbred Strains
- Rats, Mutant Strains
- Species Specificity
- Tissue Distribution
- Viscera