Article
Inter-individual differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric acid ((+)-MPPB) disposition in rats.
Biological & pharmaceutical bulletin - 1 Oct 1993
Takahara E, Nagata O, Kato H, Ohta S, Hirobe M
Abstract excerpt
Inter-individual differences of drug plasma concentration were recognized in male Sprague-Dawley (SD) rats after a p.o. or i.v. administration of (+)-MPPB. Rats could be divided into two phenotypes, the rapid-metabolizing group (RM) and the slow-metabolizing group (SM). The hepatic clearance (CLl...
Topics
- Animals
- Butyrates
- Female
- Histamine Antagonists
- Liver
- Male
- Metabolic Clearance Rate
- Phenotype
- Piperidines
- Rats
- Rats, Inbred F344
- Rats, Inbred Lew
- Rats, Sprague-Dawley
- Rats, Wistar
- Sex Factors
- Species Specificity