Genetic and developmental diversity of hepatic cytochromes P450. Warfarin and progesterone metabolism by hepatic microsomes from four inbred strains of rat.

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Article

Genetic and developmental diversity of hepatic cytochromes P450. Warfarin and progesterone metabolism by hepatic microsomes from four inbred strains of rat.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Kitareewan S, Walz F G

Abstract excerpt

Hepatic microsomes from immature and sexually mature male and female ACI/SEGHsd, F344/NHsd, SHR/NHsd, and WKY/NCrl inbred rats were used to study cytochrome P450 (P450)-catalyzed oxidations of progesterone and both enantiomers of warfarin. Strains were selected on the basis of their different, ho...

Topics

Animals
Catalysis
Chromatography, High Pressure Liquid
Cytochrome P-450 Enzyme System
Female
Genetic Variation
Isoenzymes
Liver
Male
Microsomes, Liver
Progesterone
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred ACI

Rats, Inbred F344

Rats, Inbred SHR

Rats, Inbred Strains

Rats, Inbred WKY

Stereoisomerism

Source

Open in PubMed

Identifiers

PMID: 7956737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7956737-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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